南方科技大学是由中国广东省领导和管理、深圳市举全市之力创建的一所公办创新型大学,目标是迅速建成国际化高水平研究型大学,建成中国重大科学技术研究与拔尖创新人才培养的重要基地……

南方科技大学以学分制、导师制、书院制为基础,以人才培养的个性化、小班化、国际化为特色,通过为一流的人才培养体系,培养人格健全、基础扎实、能力突出、具有国际视野、社会责任感、创新精神和实践能力的高素质人才。

南方科技大学被确定为国家高等教育综合改革试验校。2012年4月,教育部同意建校,并赋予学校探索具有中国特色的现代大学制度、探索创新人才培养模式的重大使命。

南方科技大学对本科学生采用书院制管理模式,以书院、团委、社团等平台为载体,为学生营造了精彩的大学生活。

南方科技大学本科招生采用基于高考的综合评价录取模式,即高考成绩占60%,我校自主组织的能力测试成绩占30%(其中面谈成绩为5%),高中学业水平考试成绩占10%,按考生“631”综合成绩排名从高到低录取。综合评价录取模式由我校在2012年率先实施。

南科大教育基金会由理事会、监事会、秘书处组成。理事会是基金会的最高权力机构;监事会负责检查财务和会计资料,监督理事会遵守法律和章程的情况;秘书处是基金会常设办事机构,在理事会领导下负责基金会的日常工作。

学校党委切实履行党建工作职责,不断强化班子建设和基层党组织建设,充分发挥好党委对学校各项工作的核心统领作用和各党支部的战斗堡垒作用,切实开展组织统战和党风廉政建设各项工作。学校高度重视群团组织建设,充分调动全体师生员工积极性,维护教职工的合法权益,推进学校民主管理,促进学校健康发展,全力营造齐心协力、团结向上、奋发有为的干事创业氛围。

师资队伍

首页 > 院系设置 > 生物系 > 师资队伍 > 邓兴旺

师资队伍

邓兴旺


学术委员会主任,教授

生物系

deng@sustc.edu.cn

个人简介:

邓兴旺,博士,教授,博士生导师,美国科学院院士,中组部“千人计划”引进高层次人才。曾任耶鲁大学冠名终身教授(Daniel C. Eaton Professor)。1989年于美国加州大学伯克利分校获得博士学位,1992年开始在美国耶鲁大学建立实验室,任助理教授;1995年起任该校副教授,2001年起任该校终身正教授。其领导的研究团队迄今在《细胞》、《科学》和《自然》顶级刊物上发表14篇论文,在国际刊物上共发表300多篇学术论文。2003年成为国际植物分子生物学会Kumho奖的唯一获奖者。2000年起担任北京大学-耶鲁大学植物分子遗传及农业生物技术联合中心主任,2010年入选“千人计划”,2013年入选美国科学院院士。

 

研究领域: 
邓兴旺课题组以拟南芥、水稻等为研究对象,主要从事植物光信号转导、 和分子设计育种领域的研究工作。 实验室建有配套齐全的植物基因组学、分子生物学、生物信息学等研究平台,具有长期的植物基因组学及分子生物学研究经验。实验室具体研究方向如下:
1. 植物光形态建成的分子机理
光是对于植物发育最重要也是最基本的生长信号。本实验室多年来以拟南芥为模式植物,通过遗传筛选获得了一系列光形态建成的抑制因子COP/DET/FUS。它们的突变体在暗中可以完成不同程度的光形态建成。多年的研究结果表明,这些因子在植物体内可以形成三个复合体并通过参与或调节泛素化途径来调控光信号传导。目前,在此基础上,我们将继续综合运用遗传学、生物化学、分子生物学、细胞生物学等实验手段,进一步解析光形态建成中的信号传导通路。
2. 作物分子设计育种技术体系
传统水稻育种依赖于育种家的经验,需要从大量的水稻杂交后代中挑选优良水稻株系,效率较低。随着基因组学与分子生物学技术的进步,在育种过程中对调控特定性状的基因位点进行跟踪成为了可能。我们通过利 用大量的水稻全基因组重测序信息,创制了水稻高密度单核苷酸多态性(SNP)芯片,并将其应用于水稻育种,从而使得水稻育种成为可以精确设计与控制的过程。我们创制的芯片及相应的设计流程大大提高了水稻育种效率,加快了培育高产、优质、多抗水稻品种的进程。


工作经历:
2016.07-至今:讲座教授,中国,南方科技大学生物系
2014.10-至今:筹备小组组长,中国,北京大学现代农学院(筹)
2014.7.1-至今:讲席教授(University Endowed Professor),中国,北京大学生命科学学院
2000.7-2014.6.30:长江讲座教授(兼职) (Cheung Kong Chair Professor),中国,北京大学生命科学学院
2003.5-2014.6.30:冠名终身教授(Daniel C. Eaton Professor),美国,耶鲁大学分子细胞和发育生物学系
2001.7-2014.6.30:终身教授(Full Professor),美国,耶鲁大学分子细胞和发育生物学系
2000.10-至今:主任(兼职) (Director),中国,北大-耶鲁植物遗传学和农业生物技术联合研究中心
2003-2008:共同所长(兼职) (Director),中国,北京生命科学研究所
1998.7-2001.6:终身职副教授(Associate Professor with tenure),美国,耶鲁大学分子细胞和发育生物学系
1995.7-1998.6:副教授(Associate Professor with term),美国,耶鲁大学分子细胞和发育生物学系
1992.1-1995.6:助理教授(Assistant Professor),美国,耶鲁大学分子细胞和发育生物学系
1989.5-1991.12:博士后(Postdoc),美国,加州大学伯克利分校、美国农业部植物基因研究中心,植物分子生物学


学习经历:
1985.9-1989.4: 博士(Ph.D.),美国,加州大学伯克利分校,植物生物学
1982.9-1985.7: 硕士(MS),中国,北京大学,植物生理学
1978.9-1982.7: 学士(BS),中国,北京大学,生物学


所获荣誉:
2013年: 当选为“美国科学院院士”( Elected member of US National Academy of Sciences) 
2013年: 当选为“美国科学促进协会会士”(Elected fellow of American Association for Advancement of Science)
2003年: 获国际植物分子生物学学会(ISPMB)最重要奖项“The Kumho Science International Award”(2003)
1995年: 获“美国总统青年教师奖”(Presidential Faculty Fellow Award)


代表文章:
298 Xu D, Jiang Y, Li J, Lin F, Holm M, Deng XW. (2016). BBX21, an Arabidopsis B-box protein, directly activates HY5 and is targeted by COP1 for 26S proteasome-mediated degradation. Proc Natl Acad Sci USA. 113(27):7655-7660.
297 Li, K., Yu, R., Fan, L.M., Wei, N., Chen, H. and Deng, X.W. (2016). DELLA-mediated PIF degradation contributes to coordination of light and gibberellin signalling in Arabidopsis. Nat Commun. 7:11868.
296 Sun, N., Wang, J., Gao, Z., Dong, J., He, H., Terzaghi, W., Wei, N., Deng, X.W. and Chen H. (2016). Arabidopsis SAURs are critical for differential light regulation of the development of various organs. Proc Natl Acad Sci U S A 113(21)6071-6076.
295 Yan, J., Lv, S., Hu, M., Gao, Z., He, H., Ma, Q., Deng, X.W., Zhu Z. and Wang X. (2016). Single-Molecule Sequencing Assists Genome Assembly Improvement and Structural Variation Inference. Mol Plant 9(7):1085-1087.
294 Yang, M., Huang, H., Zhang, C., Wang, Z., Su, Y., Zhu, P., Guo, Y. and Deng, X.W. (2016). Arabidopsis atypical kinase ABC1K1 is involved in red light-mediated development. Plant Cell Rep 35(6): 1213-1220.
293 Xu, D., Zhu, D. and Deng, X.W. (2016). The role of COP1 in repression of photoperiodic flowering. F1000Res 5.
292 Yu, Y., Wang, J., Shi, H., Gu, J., Dong, J., Deng, X.W. and Huang R. (2016). Salt stress and ethylene antagonistically regulate nucleocytoplasmic partitioning of COP1 to control seed germination. Plant Physiol. 170(4):2340-2350.
291 Shi, H., Liu, R., Xue, C., Shen, X., Wei, N., Deng, X.W. and Zhong S. (2016). Seedlings Transduce the Depth and Mechanical Pressure of Covering Soil Using COP1 and Ethylene to Regulate EBF1/EBF2 for Soil Emergence. Curr Biol 26(2): 139-149.
290 Ma, L., Tian, T., Lin, R., Deng, X.W., Wang H. and Li G. (2016). Arabidopsis FHY3 and FAR1 Regulate Light-Induced myo-Inositol Biosynthesis and Oxidative Stress Responses by Transcriptional Activation of MIPS1. Mol Plant 9(4): 541-557.
289 Yang, M., Wang, X., Huang, H., Ren, D., Su, Y., Zhu, P., Zhu, D., Fan, L., Chen, L., He, G. and Deng, X.W. (2016). Natural variation of H3K27me3 modification in two Arabidopsis accessions and their hybrid. J Integr Plant Biol 58(5): 466-474.
288 Dutilleul, C., Ribeiro, I., Blanc, N., Nezames, C. D., Deng, X.W., Zglobicki, P., Palacio Barrera, A. M., Atehortua, L., Courtois, M., Labas, V., Giglioli-Guivarc'h, N. and Ducos, E. (2016). ASG2 is a farnesylated DWD protein that acts as ABA negative regulator in Arabidopsis. Plant Cell Environ 39(1): 185-198.
287 Zhou, D., Chen, W., Lin, Z., Chen, H., Wang, C., Li, H., Yu, R., Zhang, F., Zhen, G., Yi, J., Li, K., Liu, Y., Terzaghi, W., Tang, X., He, H., Zhou, S. and Deng, X.W. (2016). Pedigree-based analysis of derivation of genome segments of an elite rice reveals key regions during its breeding. Plant Biotechnol J 14(2): 638-648.
286 Huang, L., Zhang, H., Zhang, H., Deng, X.W. and Wei, N. (2015). HY5 regulates nitrite reductase 1 (NIR1) and ammonium transporter1;2 (AMT1;2) in Arabidopsis seedlings. Plant Sci 238: 330-339.
285 Xu, D., Lin, F., Jiang, Y., Ling, J., Hettiarachchi, C., Tellgren-Roth, C., Holm, M., Wei, N. and Deng, X.W. (2015). Arabidopsis COP1 SUPPRESSOR 2 Represses COP1 E3 Ubiquitin Ligase Activity through Their Coiled-Coil Domains Association. PLoS Genet 11(12): e1005747.
284 Zhu, L., Bu, Q., Xu, X., Paik, I., Huang, X., Hoecker, U., Deng, X.W. and Huq, E. (2015). CUL4 forms an E3 ligase with COP1 and SPA to promote light-induced degradation of PIF1. Nat Commun 6: 7245.
283 Dong, J., Terzaghi, W., Deng, X.W. and Chen H. (2015). Multiple photomorphogenic repressors work in concert to regulate Arabidopsis seedling development. Plant Signal Behav 10(3): e1011934.
282 Huang, H., Yang, M., Su, Y., Qu, L., and Deng, X.W. (2015). Arabidopsis Atypical Kinases ABC1K1 and ABC1K3 Act Oppositely to Cope with Photodamage Under Red Light. Mol Plant 8, 1122-1124.
281 Yang, L., Li, B., Zheng, X.Y., Li, J., Yang, M., Dong, X., He, G., An, C., and Deng, X.W. (2015). Salicylic acid biosynthesis is enhanced and contributes to increased biotrophic pathogen resistance in Arabidopsis hybrids. Nat Commun 6, 7309.
280 Li, K., Gao, Z., He, H., Terzaghi, W., Fan, L.M., Deng, X.W., and Chen, H. (2015). Arabidopsis DET1 Represses Photomorphogenesis in Part by Negatively Regulating DELLA Protein Abundance in Darkness. Mol Plant 8, 622-630.
279 Shi, H., Wang, X., Mo, X., Tang, C., Zhong, S., and Deng, X.W. (2015). Arabidopsis DET1 degrades HFR1 but stabilizes PIF1 to precisely regulate seed germination. Proc Natl Acad Sci U S A. 112, 3817-3822.
278 Zhang, H., Zhao, X., Li, J., Cai, H., Deng, X.W., and Li, L. (2014). MicroRNA408 is critical for the HY5-SPL7 gene network that mediates the coordinated response to light and copper. Plant Cell 26, 4933-4953.
277 Shi, H., Wang, X., Mo, X., Tang, C., Zhong, S., and Deng, X.W. (2015). Arabidopsis DET1 degrades HFR1 but stabilizes PIF1 to precisely regulate seed germination. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1502405112.
276 Kim, S. H., Kim, H., Seo, K. I., Kim, S. H., Chung, S., Huang, X., Yang, P., Deng, X.W., and Lee, J. H. (2014). DWD HYPERSENSITIVE TO UV-B 1 is negatively involved in UV-B mediated cellular responses in Arabidopsis. Plant Mol Biol 86: 571-583.
275 Kim, S. H., Lee, J. H., Seo, K. I., Ryu, B., Sung, Y., Chung, T., Deng, X.W., and Lee, J. H (2014). Characterization of a Novel DWD Protein that Participates in Heat Stress Response in Arabidopsis. Mol Cells 37: 833-840.
274 Dong, J., Tang, D., Gao, Z., Yu, R., Li, K., He, H., Terzaghi, W., Deng, X.W. and Chen, H. (2014). Arabidopsis DE-ETIOLATED1 Represses Photomorphogenesis by Positively Regulating Phytochrome-Interacting Factors in the Dark. Plant Cell 26: 3630-3645.
273 Wang, L., Li, J., Zhou, Q., Yang, G., Ding, X. L., Li, X., Cai, C. X., Zhang, Z., Wei, H. Y., Lu, T. H., Deng, X.W. and Huang, X. H. (2014). Rare earth elements activate endocytosis in plant cells. Proc Natl Acad Sci U S A. 111:12936-12941.
272 Chen, F., Li, B., Demone, J., Charron, J.B., Shi, X., and Deng, X.W. (2014). Photoreceptor partner FHY1 has an independent role in gene modulation and plant development under far-red light. Proc Natl Acad Sci U S A 111:11888-11893.
271 Huang, X., Ouyang, X., and Deng, X.W. (2014). Beyond repression of photomorphogenesis: role switching of COP/DET/FUS in light signaling. Curr Opin Plant Biol 21C, 96-103.
270 Ouyang, X., Huang, X., Jin, X., Chen, Z., Yang, P., Ge, H., Li, S., and Deng, X.W. (2014). Coordinated photomorphogenic UV-B signaling network captured by mathematical modeling. Proc Natl Acad Sci U S A 111, 11539-11544.
269 Wang, Y., Fan, X., Lin, F., He, G., Terzaghi, W., Zhu, D., and Deng, X.W. (2014). Arabidopsis noncoding RNA mediates control of photomorphogenesis by red light. Proc Natl Acad Sci U S A 111, 10359-10364.
268 Xu, D., Lin, F., Jiang, Y., Huang, X., Li, J., Ling, J., Hettiarachchi, C., Tellgren-Roth, C., Holm, M., and Deng, X.W. (2014). The RING-Finger E3 Ubiquitin Ligase COP1 SUPPRESSOR1 Negatively Regulates COP1 Abundance in Maintaining COP1 Homeostasis in Dark-Grown Arabidopsis Seedlings. Plant Cell 26, 1981-1991.
267 Chen, F., Li, B., Li, G., Charron, J.B., Dai, M., Shi, X., and Deng, X.W. (2014). Arabidopsis Phytochrome A Directly Targets Numerous Promoters for Individualized Modulation of Genes in a Wide Range of Pathways. Plant Cell 26, 1949-1966.
266 Jin, D., Li, B., Deng, X.W., and Wei, N. (2014). Plant COP9 signalosome subunit 5, CSN5. Plant Sci 224, 54-61.
265 Huang, X., Yang, P., Ouyang, X., Chen, L., and Deng, X.W. (2014). Photoactivated UVR8-COP1 module determines photomorphogenic UV-B signaling output in Arabidopsis. PLoS Genet 10, e1004218.
264 Zhong, S., Shi, H., Xue, C., Wei, N., Guo, H., and Deng, X.W. (2014). Ethylene-orchestrated circuitry coordinates a seedling's response to soil cover and etiolated growth. Proc Natl Acad Sci U S A 111, 3913-3920.
263 Xu, D., Li, J., Gangappa, S.N., Hettiarachchi, C., Lin, F., Andersson, M.X., Jiang, Y., Deng, X.W., and Holm, M. (2014). Convergence of Light and ABA signaling on the ABI5 promoter. PLoS Genet 10, e1004197.
262 Xu, X., Paik, I., Zhu, L., Bu, Q., Huang, X., Deng, X.W., and Huq, E. (2014). PHYTOCHROME INTERACTING FACTOR1 Enhances the E3 Ligase Activity of CONSTITUTIVE PHOTOMORPHOGENIC1 to Synergistically Repress Photomorphogenesis in Arabidopsis. Plant Cell 26, 1992-2006.
261 Wang, Y., Wang, X., Deng, W., Fan, X., Liu, T.T., He, G., Chen, R., Terzaghi, W., Zhu, D., and Deng, X.W. (2014). Genomic features and regulatory roles of intermediate-sized non-coding RNAs in Arabidopsis. Mol Plant 7, 514-527.
260 Seo, K.I., Lee, J.H., Nezames, C.D., Zhong, S., Song, E., Byun, M.O., and Deng, X.W. (2014). ABD1 is an Arabidopsis DCAF substrate receptor for CUL4-DDB1-based E3 ligases that acts as a negative regulator of abscisic acid signaling. Plant Cell 26, 695-711.
259 Irigoyen, M.L., Iniesto, E., Rodriguez, L., Puga, M.I., Yanagawa, Y., Pick, E., Strickland, E., Paz-Ares, J., Wei, N., De Jaeger, G., Rodriguez, P.L., Deng, X.W., and Rubio, V. (2014). Targeted degradation of abscisic acid receptors is mediated by the ubiquitin ligase substrate adaptor DDA1 in Arabidopsis. Plant Cell 26, 712-728.
258 Chen, W., Chen, H., Zheng, T., Yu, R., Terzaghi, W.B., Li, Z., Deng, X.W., Xu, J., and He, H. (2014). Highly efficient genotyping of rice biparental populations by GoldenGate assays based on parental resequencing. Theor Appl Genet 127, 297-307.
257 Chen, S., He, H., and Deng, X.W. (2014). Allele-specific DNA methylation analyses associated with siRNAs in Arabidopsis hybrids. Science China. Life sciences.
256 Chen, H., Xie, W., He, H., Yu, H., Chen, W., Li, J., Yu, R., Yao, Y., Zhang, W., He, Y., Tang, X., Zhou, F., Deng, X.W., and Zhang, Q. (2014). A high-density SNP genotyping array for rice biology and molecular breeding. Mol Plant 7, 541-553.
255 Zhang, H., Deng, X.W., and Li, L. (2013). Analysis of allele-specific gene expression using a target-oriented tiling microarray assay. Methods in molecular biology (Clifton, N.J.) 1067, 65-76.
254 Yu, Y., Wang, J., Zhang, Z., Quan, R., Zhang, H., Deng, X.W., Ma, L., and Huang, R. (2013). Ethylene promotes hypocotyl growth and HY5 degradation by enhancing the movement of COP1 to the nucleus in the light. PLoS Genet 9, e1004025.
253 Wang, J., Yu, Y., Zhang, Z., Quan, R., Zhang, H., Ma, L., Deng, X.W., and Huang, R. (2013). Arabidopsis CSN5B interacts with VTC1 and modulates ascorbic acid synthesis. Plant Cell 25, 625-636.
252 Shi, H., Zhong, S., Mo, X., Liu, N., Nezames, C.D., and Deng, X.W. (2013). HFR1 sequesters PIF1 to govern the transcriptional network underlying light-initiated seed germination in Arabidopsis. Plant Cell 25, 3770-3784.
251 Liu, T.T., Zhu, D., Chen, W., Deng, W., He, H., He, G., Bai, B., Qi, Y., Chen, R., and Deng, X.W. (2013). A global identification and analysis of small nucleolar RNAs and possible intermediate-sized non-coding RNAs in Oryza sativa. Mol Plant 6, 830-846.
250 Liu, C., Guo, L.Q., Menon, S., Jin, D., Pick, E., Wang, X., Deng, X.W., and Wei, N. (2013). COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase. J Biol Chem 288, 20443-20452.
249 Li, J., Yang, L., Jin, D., Nezames, C.D., Terzaghi, W., and Deng, X.W. (2013). UV-B-induced photomorphogenesis in Arabidopsis. Protein & cell 4, 485-492.
248 Li, B., Duan, H., Li, J., Deng, X.W., Yin, W., and Xia, X. (2013). Global identification of miRNAs and targets in Populus euphratica under salt stress. Plant Mol Biol 81, 525-539.
247 Huang, X., Ouyang, X., Yang, P., Lau, O.S., Chen, L., Wei, N., and Deng, X.W. (2013). Conversion from CUL4-based COP1-SPA E3 apparatus to UVR8-COP1-SPA complexes underlies a distinct biochemical function of COP1 under UV-B. Proc Natl Acad Sci U S A 110, 16669-16674.
246 Huang, X., and Deng, X.W. (2013). Organization of protein complexes under photomorphogenic UV-B in Arabidopsis. Plant Signal Behav 8.
245 He, G., He, H., and Deng, X.W. (2013). Epigenetic variations in plant hybrids and their potential roles in heterosis. J Genet Genomics 40, 205-210.
244 He, G., Chen, B., Wang, X., Li, X., Li, J., He, H., Yang, M., Lu, L., Qi, Y., and Deng, X.W. (2013). Conservation and divergence of transcriptomic and epigenomic variation in maize hybrids. Genome Biol 14, R57.
243 Guo, L., Nezames, C.D., Sheng, L., Deng, X.W., and Wei, N. (2013). Cullin-RING ubiquitin ligase family in plant abiotic stress pathways(F). J Integr Plant Biol 55, 21-30.
242 Franciosini, A., Lombardi, B., Iafrate, S., Pecce, V., Mele, G., Lupacchini, L., Rinaldi, G., Kondou, Y., Gusmaroli, G., Aki, S., Tsuge, T., Deng, X.W., Matsui, M., Vittorioso, P., Costantino, P., and Serino, G. (2013). The Arabidopsis COP9 SIGNALOSOME INTERACTING F-BOX KELCH 1 protein forms an SCF ubiquitin ligase and regulates hypocotyl elongation. Mol Plant 6, 1616-1629.
241 Dai, M., Xue, Q., McCray, T., Margavage, K., Chen, F., Lee, J.H., Nezames, C.D., Guo, L., Terzaghi, W., Wan, J., Deng, X.W., and Wang, H. (2013). The PP6 Phosphatase Regulates ABI5 Phosphorylation and Abscisic Acid Signaling in Arabidopsis. Plant Cell 25, 517-534.
240 Chen, H., He, H., Zhou, F., Yu, H., and Deng, X.W. (2013). Development of genomics-based genotyping platforms and their applications in rice breeding. Curr Opin Plant Biol 16, 247-254.
239 Bowler, C., Botto, J., and Deng, X.W. (2013). Photomorphogenesis, B-Box transcription factors, and the legacy of Magnus Holm. Plant Cell 25, 1192-1195.
238 Zhu, D., and Deng, X.W. (2012). A non-coding RNA locus mediates environment-conditioned male sterility in rice. Cell Res 22, 791-792.
237 Zhou, H., Zhao, J., Yang, Y., Chen, C., Liu, Y., Jin, X., Chen, L., Li, X., Deng, X.W., Schumaker, K.S., and Guo, Y. (2012). Ubiquitin-specific protease16 modulates salt tolerance in Arabidopsis by regulating Na(+)/H(+) antiport activity and serine hydroxymethyltransferase stability. Plant Cell 24, 5106-5122.
236 Zhong, S., Shi, H., Xue, C., Wang, L., Xi, Y., Li, J., Quail, P.H., Deng, X.W., and Guo, H. (2012). A molecular framework of light-controlled phytohormone action in Arabidopsis. Curr Biol 22, 1530-1535.
235 Zhao, J., Huang, X., Ouyang, X., Chen, W., Du, A., Zhu, L., Wang, S., Deng, X.W., and Li, S. (2012). OsELF3-1, an ortholog of Arabidopsis early flowering 3, regulates rice circadian rhythm and photoperiodic flowering. PLoS One 7, e43705.
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