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Faculty

XinYuan Liu


Associate Professor

Department of Chemistry

0755-88018314

liuxy@sustc.edu.cn

Dr. Xin-Yuan Liu received his Bachelor degree from the department of chemistry, Anhui Normal University in 2001 and a Master degree in 2004 from Anhui Normal University in Cooperation with Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China. Then, he became a Ph.D. candidate in Department of Chemistry, the University of Hong Kong under the supervision of Prof. Chi-Ming Che, and has been awarded a Ph.D. degree in 2010. He then successfully applied a Post-doctoral Fellow position in the University of Hong Kong and continued to work in the laboratory of Prof. Che. In 2011, he joined in the group of Prof. Carlos F. Barbas III at the Scripps Research Institute for a postdoc position. In September of 2012, Dr. Liu joined in the Department of Chemistry, SUSTC, and has set up an independent organic chemistry’s research group.

His research interests are focused on transition-metal and organocatalyst-catalyzed organic chemistry, homogeneous and heterogeneous catalysis, organofluorine chemistry, and the application of chemistry in biological and medicinal chemistry. He has published more than forty research papers in international journals, including Angewandte Chemie International Edition, Chemical Communications, Organic Letters, Chemistry – A European Journal, ACS Catalysis. Citation times for his research papers have been up to 1300. Dr. Liu has been awarded Award for Outstanding Research Postgraduate Student for 2009-2010 in The University of Hong Kong (2011), and Peacock Plan Awardee, Shenzhen (2013), and so on.

 

Research interests:

 

◆ Catalytic functionalization of unactivated alkenes and alkynes
◆ Asymmetric radical chemistry
◆ Design and application of homogenous and heterogeneous catalysis
◆ Organofluorine chemistry.

 

Educational background:

 

◆ Ph.D., in Organic Chemistry, The University of Hong Kong, 2010;

◆ M.S., in Organic Chemistry, Anhui Normal University in Cooperation with Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 2004;

◆ B.S., in Chemistry, Anhui Normal University, 2001. 


Professional experience:

 

◆ 2012.9, Associate Professor, South University of Science and Technology of China;

◆ 2011-2012, Research Associate, the Scripps Research Institute, USA; 

◆ 2010-2011, Post-doctoral Fellow, The University of Hong Kong;

◆ 2004-2005, Research Assistant, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.

 

Honors & Awards:

 

◆ 2011,Award for Outstanding Research Postgraduate Student for 2009-2010 in The University of Hong Kong

◆ 2013,Peacock Plan Awardee, Shenzhen 

 

Publications:

 

1.    Zhi-Jia Fang, Sheng-Cai Zheng, Zhen Guo, Jing-Yao Guo, Bin Tan,* Xin-Yuan Liu*, Asymmetric Synthesis of Axially Chiral Isoquinolones: Nickel-Catalyzed Denitrogenative Transannulation Angew. Chem. Int. Ed. 2015, 54, DOI: 10.1002/anie. 201503207.
2.    Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan,* Xin-Yuan Liu*, Brønsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter Angew. Chem. Int. Ed. 2015, 54, DOI: 10.1002/anie.201501762.
3.    Peng Yu, Sheng-Cai Zheng, Ning-Yuan Yang, Bin Tan,* Xin-Yuan Liu*,Phosphine-Catalyzed Remote β-C-H Functionalization of Amine Triggered by Trifluoromethylation of Alkene: One-Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles, Angew. Chem. Int. Ed. 2015, 54, 4041-4045 (Selected as Cover Picture). 
4.    Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*, and Xin-Yuan Liu* “Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene” Angew. Chem. Int. Ed. 2014, 53, 11890. 
Highlighted in Synfacts, 2014, 10, 1281.
5.    Ming-Yue Wu, Wei-Wei He, Xin-Yuan Liu*, Bin Tan,* Asymmetric Construction of Spirooxindoles via Organocatalytic Multicomponent Reactions of Diazooxindoles Angew. Chem. Int. Ed. 2015, 54, DOI: 10.1002/anie. 201504640.
6.    Dao-Juan Cheng, Liang Yan, Shi-Kai Tian,* Ming-Yue Wu, Lu-Xin Wang, Zi-Li Fan, Sheng-Cai Zheng, Xin-Yuan Liu,* and Bin Tan* “Highly Enantioselective Kinetic Resolution of Axially Chiral BINAM Derivatives Catalyzed by a Brønsted Acid” Angew. Chem. Int. Ed. 2014, 53, 3684. 
Highlighted in Synfacts, 2014, 10, 530.
7.    Lin Huang, Jin-Shun Lin, Bin Tan,* Xin-Yuan Liu*, Alkene Trifluoromethylation-Initiated Remote α-Azidation of Carbonyl Compounds toward Trifluoromethyl γ-Lactam and Spirobenzofuranone-lactam ACS Cat. 2015, 5, 2826-2831.
8.    Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu*, Metal-Free Direct 1,6- and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes Org. Lett. 2015, 17, 1589-1592.
9.    Lin Huang, Sheng-Cai Zheng, Bin Tan,* Xin-Yuan Liu*, Trifluoromethylation-Initiated Remote Cross-Coupling of Carbonyl Compounds to Form Carbon–Heteroatom/Carbon Bonds Chem. Eur. J. 2015, 21, 6718.
10.    Can-Liang Ma, Xiao-Long Yu, Xiao-Long Zhu, Yong-Zhou Hu, Xiao-Wu Dong, Bin Tan*, and Xin-Yuan Liu* “Platinum-Catalyzed Tandem Cyclization Reaction to Multiply Substituted Indolines under Microwave-Assisted Conditions” Adv. Synth. Catal. 2015, 357,569.
11.    Lei Li, Jing-Yao Guo, Xing-Guo Liu, Su Chen, Yong Wang, Bin Tan*, and Xin-Yuan Liu* “Amide Groups Switch Selectivity: C-H Trifluoromethylation of α,β-Unsaturated Amides and Subsequent Asymmetric Transformation” Org. Lett., 2014, 16, 6032.
12.    Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan,* and Xin-Yuan Liu* “Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles” J. Org. Chem. 2014, 79, 7084.
13.    Xing-Li Zhu, Jin-Hui Xu, Dao-Juan Cheng, Li-Jiao Zhao, Xin-Yuan Liu* and Bin Tan* “In Situ Generation of Electrophilic Trifluoromethylthio Reagents for Enantioselective Trifluoromethylthiolation of Oxindoles” Org. Lett. 2014, 16, 2192.
Highlighted in Synfacts, 2014, 10, 754.
14.    Ya-Ping Xiong, Ming-Yue Wu, Xiang-Yu Zhang, Can-Liang Ma, Lin Huang, Li-Jiao Zhao, Bin Tan* and Xin-Yuan Liu* “Direct Access to α-CF3-enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer-Schuster Rearrangement” Org. Lett. 2014, 16, 1000.
This work is highlighted on the website http:// http://www.organic-chemistry.org/abstracts/lit4/389.shtm
15.    Lei Li, Min Deng, Sheng-Cai Zheng, Ya-Ping Xiong, Bin Tan* and Xin-Yuan Liu*. “Metal-Free Direct Intramolecular Carbotrifluoromethylation of Alkenes to Functionalized Trifluoromethyl Azaheterocycles” Org. Lett. 2014, 16, 504.
16.    Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan,* and Xin-Yuan Liu*. “Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles” Chem. Eur. J. 2014, 20, 1332.
17.    Tao Liu, Da-Qiang Li, Si-Yu Wang Yong-Zhou Hu, Xiao-Wu Dong,* Xin-Yuan Liu,* and Chi-Ming Che “Straightforward Installation of Carbon-Halogen, Carbon-Oxygen and Carbon-Carbon Bonds within Metal–Organic Frameworks via Direct C-H Functionalization” Chem. Commun., 2014, 50,13261.
   Highlighted in Synfacts, 2014, 10, 1272.
18. Tao Liu, Jin-Xin Che, Yong-Zhou Hu, Xiao-Wu Dong,* Xin-Yuan Liu,* Chi-Ming Che “Alkenyl/thiol-derived Metal–Organic Frameworks via Post-Synthetic Modification for Effective Mercury Adsorption” Chem. Eur. J. 2014, 20,14090.

19. Xiao-Wu Dong, Tao Liu, Yong-Zhou Hu*, Xin-Yuan Liu*, Chi-Ming Che. Urea Postmodified in Metal-Organic Framework as Catalytically Active Hydrogen-Bond-Donating Heterogeneous Catalyst Chem. Commun., 2013, 49, 7681. 
  Highlighted with a front cover in Chem. Commun.; 
  Selected as HOT Chem. Comm. articles for May; 
  Highlighted in Synfacts, 2013, 9, 1251. 

20. Gaosheng Yang,* Chongrong Luo, Xiaolong Mu, Tingting Wang and Xin-Yuan Liu*, Highly efficient enantioselective three-component synthesis of 2-amino-4H-chromenes catalysed by chiral tertiary amine-thioureas Chem. Commun. 2012, 48, 5880-5882.

 

Graduate & Postdoctoral Publications

 

1. Xin-Yuan Liu, Ya-Ping Xiao, Fung-Ming Siu, Li-Chen Ni, Yong Chen, Lin Wang, and Chi-Ming Che*, “Highly regio-, diastereo- and enantioselective one-pot gold/chiral Brønsted acid-catalysed cascade synthesis of bioactive diversely substituted tetrahydroquinolines” Org. Biomol. Chem. 2012, 10, 7208-7219.

2. Xin-Yuan Liu,[+] Zhen Guo,[+] Sijia Dong,[+] Xiao-Hua Li, and Chi-Ming Che*, “Highly efficient and diastereoselective gold(I)-catalyzed synthesis of tertiary amines from secondary amines and alkynes: substrate scope and mechanical insights” Chem. Eur. J. 2011, 17, 12932-12945. [+]denotes equal contribution

3. Ya-Ping Xiao,[+] Xin-Yuan Liu,[+] and Chi-Ming Che*, “Efficient gold(I)-catalyzed direct intramolecular hydroalkylation of unactivated alkenes with simple α-ketones” Angew. Chem. Int. Ed. 2011, 50, 4937-4941. [+]denotes equal contribution

4. Xin-Yuan Liu, Chi-Ming Che*, “Highly enantioselective synthesis of chiral secondary amines by gold(I)/chiral Brønsted acid-catalyzed tandem intermolecular hydroamination and transfer hydrogenation reactions” Org. Lett. 2009, 11, 4204-4207.

5. Xin-Yuan Liu, Chi-Ming Che*, “Highly efficient and regioselective platinum(II)-catalyzed tandem synthesis of multiply substituted indolines and tetrahydroquinolines” Angew. Chem. Int. Ed. 2009, 48, 2367-2371.

6. Xin-Yuan Liu, Chi-Ming Che*, “A highly efficient and selective AuI-catalyzed tandem synthesis of diversely substituted pyrrolo[1,2-α]quinolines in aqueous medium” Angew. Chem. Int. Ed. 2008, 47, 3805-3810.

7. Xin-Yuan Liu, Pan Ding, Jie-Sheng Huang, Chi-Ming Che*, “Synthesis of substituted 1,2-dihydroquinolines and quinolines from aromatic amines and alkynes by gold(I)-catalyzed tandem hydroamination-hydroarylation under microwave-assisted conditions” Org. Lett. 2007, 9, 2645-2648.

8. Xin-Yuan Liu, Cheng-Hui Li, Chi-Ming Che*, “Phosphine gold(I)-catalyzed hydroamination of alkenes under thermal and microwave-assisted conditions” Org. Lett. 2006, 8, 2707-2710. 

9. Xin yuan Liu, Xiaoyu Wu, Zhuo Chai, Yongyong Wu, Gang Zhao*, Shizheng Zhu*, “Highly effective and recyclable dendritic ligands for the enantioselective aryl transfer reactions to aldehydes” J. Org. Chem. 2005, 70, 7432-7435.

 

Selected Works Highlighted by Others or Featured by Journal Editors


1. “Phosphine Gold(I)-Catalyzed Hydroamination of Alkenes under Thermal and Microwave-Assisted Conditions” (X.-Y. Liu, C.-H. Li, C.-M. Che, Org. Lett., 2006, 8, 2707-2710) is featured on the ACS Publications website as one of “Organic Letters' Hot Papers” based on citation data obtained from Thomson ISI.
2.    “Synthesis of Substituted 1,2-Dihydroquinolines and Quinolines from Aromatic Amines and Alkynes by Gold(I)-Catalyzed Tandem Hydroamination-Hydroarylation under Microwave-Assisted Conditions” (X.-Y. Liu, P. Ding, J.-S. Huang, C.-M. Che, Org. Lett., 2007, 9, 2645-2648) is selected on the ACS Publications website in 2009 as Top 20 most-cited articles published in the last three years.
3.    “Synthesis of Substituted 1,2-Dihydroquinolines and Quinolines from Aromatic Amines and Alkynes by Gold(I)-Catalyzed Tandem Hydroamination-Hydroarylation under Microwave-Assisted Conditions” (X.-Y. Liu, P. Ding, J.-S. Huang, C.-M. Che, Org. Lett., 2007, 9, 2645-2648) is highlighted on the website http://www.organic-chemistry.org/Highlights/2007/15August.shtm
4.    “Highly Efficient and Regioselective Platinum(II)-Catalyzed Tandem Synthesis of Multiply Substituted Indolines and Tetrahydroquinolines” (X.-Y. Liu, C.-M. Che, Angew. Chem. Int. Ed., 2009, 48, 2367-2371) is selected by the Editorial Board of SYNFACTS and published in SYNFACTS issue 06/09.
5.    “Synthesis of Chiral Secondary Amines by Gold(I)-Chiral Bronsted Acid Catalysis” (X.-Y. Liu, C.-M. Che, Org. Lett., 2009, 11, 4204-4207) is selected by the Editorial Board of SYNFACTS and published in SYNFACTS issue 12/09.

Research Fields

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